Ivf or icsi which is better

Plachot et al concluded that ICSI procedure in sibling oocytes prevents the cancellation of embryo transfer following complete fertilization failure with conventional IVF Ou et al reported higher fertilization rate with ICSI in low oocytes retrieval cycles and suggested this technique may be better than conventional IVF in these cases 6.

However our research was done in normoresponder patients and cycles with retrieved oocytes lower than 5 were excluded from the study. Biological differences between the process of fertilization during ICSI and conventional IVF may contribute to decrease of blastocyst formation in ICSI cycles; The reasons for this comment may be the harmful effects of ICSI on oocyte and the further development of embryo or the inaccurate positioning of injection needle in regard to the second meiotic spindle location; damage of the spindle can cause mistake in the first cleavage divisions.

However Dumoulin et al reported that technical errors has a minor impact on blastocyst development and cannot clearly explain the damaged blastocyst formation after ICSI 3 - 4 , There are considerable increased risk of sex and autosomal chromosome anomalies, and imprinting disorders in ICSI children.

So the long term consequences and safety of ICSI are still debate 1 , 8 , 21 - According to recent study, the routine use of ICSI does not improved fertilization, implantation and chemical pregnancy rates and is not recommended in non-male factor, normozoospermic patients and further large prospective investigations is needed. The authors are grateful to Farimah Shams for her assistance in statistical analysis and the laboratory staff of the Research and Clinical Center for Infertility for their assistance.

National Center for Biotechnology Information , U. Iran J Reprod Med. Maryam Eftekhar , M. Find articles by Maryam Eftekhar. Find articles by Farnaz Mohammadian. Find articles by Fariba Yousefnejad. Find articles by Behnaz Molaei. Find articles by Abbas Aflatoonian. Author information Article notes Copyright and License information Disclaimer.

Email: mohamadian zums. Copyright notice. This article has been corrected. See Int J Reprod Biomed. This article has been cited by other articles in PMC. ICSI versus conventional techniques for oocyte insemination during IVF in patients with non-male factor subfertility: a Cochrane review. World Health Organisation. WHO laboratory manual for the examination and processing of human semen.

Intracytoplasmic sperm injection and conventional in vitro fertilization for sibling oocytes in cases of unexplained infertility and borderline semen. J Assisted Reprod Genet. The role of in vitro fertilization and intracytoplasmic sperm injection in couples with unexplained infertility after failed intrauterine insemination.

Conventional in-vitro fertilization versus intracytoplasmic sperm injection in sibling oocytes from couples with tubal infertility and normozoospermic semen. Intracytoplasmic sperm injection increased fertilization and good quality embryo formation in patients with non-male factor indications for in-vitro fertilization: a prospective randomized study. Intracytoplasmic sperm injection improving embryo quality: comparison of the sibling oocytes of non-male-factor couples.

A comparative analysis of embryo implantation potential in patients with severe teratozoospermia undergoing in-vitro fertilization with a high insemination concentration or intracytoplasmic sperm injection. Confirmation of the beneficial effects of brief coincubation of gametes in human in vitro fertilization. Download references. You can also search for this author in PubMed Google Scholar. All authors contributed to the concept and design of the study, statistical evaluations, wrote and contributed to substantial changes of the manuscript.

The final draft before submission was approved by all authors. Correspondence to Raoul Orvieto. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions.

Farhi, J. Reprod Biol Endocrinol 17, 30 Download citation. Received : 18 January Accepted : 27 February Published : 07 March Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Backgroud In order to maximize In vitro fertilization IVF success rates in advanced- age patients, it has been suggested to favor the use of intracytoplasmic sperm injection ICSI over conventional insemination CI , with the notion that ICSI would serve as a tool to overcome interference in sperm oocyte interaction and sperm oocyte penetration issues that can be related to maternal age and are not due to sperm abnormalities.

Results Five hundreds and four oocytes were collected from 52 eligible patients. Introduction Intracytoplasmic sperm injection ICSI was developed for the treatment of couples with severe male-factor infertility to enable fertilization and pregnancy rates regardless of semen characteristics. The sperm are then aspirated from the sperm drop into a microtool called an ICSI needle.

Once the sperm is in the ICSI needle, the embryologist moves it to a media drop containing the eggs. The egg to be injected is held gently in place by a microtool called a holding pipette, which exerts a light suction on the egg, allowing the embryologist to place the egg in perfect injection position.

The embryologist then brings the ICSI needle with the sperm down to the other media drop and lines it up with the egg. The ICSI needle is gently pressed into the side of the egg below the polar body. Embryologists typically combine several pairs of egg and sperm depending on how many eggs were retrieved during that cycle.

Only mature eggs are injected via ICSI, and not all retrieved eggs reach maturity. The polar body indicates that the egg is mature and ready for insemination. Eggs must have all of the protective granulosa cells removed prior to ICSI so that the polar body can be visualized. This process was initially developed for men whose sperm had low motility , and could not penetrate the zona pellucida.

The process that leads up to the insemination of eggs with sperm is called controlled ovarian hyperstimulation. Once the eggs have been retrieved during an in-office procedure called an egg oocyte retrieval, it is time for the true IVF to begin. It is strongly marketed to the public and promoted in social media by individual doctors, clinics and corporations. Doctors and clinics also compete for patients, often offering unproven therapies. Read more: The business of IVF: how human eggs went from simple cells to a valuable commodity.

Couples may overlook a doctor seeking to practise fertility medicine based solely on evidence, and instead find a nearby clinic or doctor prepared to offer add-ons they believe will improve their chance of a baby. Infertility is distressing and, in most cases, can be easily treated with good advice, simple drugs and, if needed, quality assisted reproductive procedures such as IVF.

However, unrestrained, unnecessary use of ICSI is a salutary example of why we need to act on widely accepted evidence. Until now, the fertility industry has promoted self-regulation over being made to follow government-imposed, evidence-based guidelines of which fertility treatments are needed. Couples with infertility belong to a very vulnerable group who will do almost anything to achieve a pregnancy.