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For the first one to two weeks of Champix treatment, you can carry on smoking. Although you are not recommended to smoke while taking treatment, Champix can also reduce the enjoyment of cigarettes if you do smoke when on treatment.

Champix is not expected to affect the way other drugs or medication work. Stopping smoking with or without Champix may alter the way some medications work — consult your doctor before commencing treatment to be sure. Giving up smoking with or without treatment can cause various symptoms including changes of mood such as feeling depressed, irritable, frustrated or anxious.

It can cause sleeplessness and difficulty concentrating, decreased heart rate and increased appetite or weight gain. The most common side-effect associated with Champix is nausea. Other common side effects include headache, difficulty sleeping and abnormal dreams.

Champix may produce dizziness and sleepiness. You should not drive, operate complex machinery or engage in any other potentially hazardous activities until you know whether this medication affects your ability to perform these activities. For some people, stopping smoking with or without treatment has been associated with an increased risk of experiencing changes in thinking or behaviour, feelings of depression and anxiety and can be associated with worsening of psychiatric illness.

If you have a history of psychiatric illness you should discuss this with your doctor or pharmacist. Depressed moods may appear during smoking cessation with or without treatment. Depression, rarely including suicidal thoughts or suicide attempts, has been reported in patients undergoing a smoking cessation, including those using Champix. If these symptoms persist when you stop taking Champix your doctor should continue to monitor you closely until you are feeling better.

Champix should be discontinued immediately if you are concerned about agitation, depressed moods, changes in your behaviour, or if you develop suicidal thoughts or behaviour. If you are worried about any of the side effects, if they become serious or if you notice side effects not in the package leaflet, you should consult your doctor or pharmacist.

There are receptors for nicotine in the brain called nicotinic acetylcholine receptors. When cigarette smoke is inhaled, nicotine attaches to these receptors and this binding activates the mesolimbic dopamine system. This triggered release of dopamine results in a feeling of pleasure and the desire to repeat this feeling reinforces the need to keep smoking. Varenicline as varenicline tartrate is the medicinal ingredient of Champix.

New shortages not listed on the SPS website, can be reported using our shortage reporting tool. Barai Pharmacy in Sutton, This will apply across Supply disruption alert: Champix Varenicline 0. Patients currently prescribed this treatment will require review and switching to nicotine replacement therapy NRT unless contraindicated.